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Annals of the Rheumatic Diseases
The liver needs time to adapt to enhanced glucagon signaling
It is also approved to reduce the risk of heart attack, stroke, and even death in people with type 2 diabetes
Many GPCRs, including GLP-1R and GIPR, couple to the stimulatory G protein, Gs, to activate adenylyl cyclase and produce the second messenger cyclic AMP
10.1039/c2np20009k 35 RuizJ.BlumwaldE
The risk is not necessarily that tirzepatide is definitively harmful to infants, but rather that no adequate human studies exist to confirm safety margins or identify rare adverse effects
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