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10.1177/2048872617710789 59 HuangK.QueJ.HuZ.YuY.ZhouY.WangL.et al (2020)

Protocol 4: nasal spray approach Goal: Needle-free administration with acceptable bioavailability trade-off Duration: 20 days active, then 4-6 months off Schedule: Days 1-20: 10-15 mg epitalon intranasally, divided into 2-3 daily doses Days 21-180: Off cycle Repeat 1-2 times per year Formulation: Reconstitute in saline with 3 percent DMSO for improved nasal absorption

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They found only one small exploratory ulcerative-colitis study with too little detail for firm conclusions, no clinical studies in Crohn's disease, and continuing concerns about product quality and safety

Accordingly, we combined the most effective reversion positions with Glu72Arg and applied them to the X(GD_L)aX(GD_L)c background to generate X(GD_L)dX(GD_L)f (Fig

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