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Neurology (2008) 11

Therefore, by inhibiting NF-B, iNOS, and NO activities through SIRT1 activation, SP or L-cars protective impact would be linked to a decrease in the formation of oxidative free radicals and pro-inflammatory mediators

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It has been suggested that signaling between enteric glia and astrocytes in the brain is implicated in the pathogenesis of some neurodegenerative disorders, such as Alzheimers dementia and Parkinsons disease (PD), that are strongly associated with MDD [33, 34]

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