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Although some GLP-1RAs do not seem to naturally cross the bloodbrain barrier, they may still reach relevant brain areas via circumventricular sites and, possibly, via active transporters 4,5

Rare adverse effects that may indirectly affect the kidneys include pancreatitis (which can cause systemic inflammation and prerenal AKI) and allergic reactions

The signs that matter clinically are carpal-tunnel-like wrist symptoms, persistent joint pain, or elevated blood glucose, these usually indicate IGF-1 is too high and dosing needs to be reduced

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It describes patients with documented depression or anxiety disorder already on sertraline who also have type 2 diabetes, prediabetes or weight-management goals

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