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Pinch the Skin: Gently pinch a one-to-two-inch fold of skin and fat between your thumb and forefinger

The clinical studies demonstrating wrinkle reduction, collagen increase, and elasticity improvement all used topical delivery, confirming its effectiveness for most users' anti-aging goals

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The only human trial ever registered (NCT02637284) was cancelled in 2016 without publishing results

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Multivariate models based on metabolite features were associated with postoperative improvement, with strongest performance observed for cognitive outcomes