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this process is impaired in diabetes, contributing to diabetic complications (Yapislar 2012)

FIGURE 5 The primary source of ROS in the endoplasmic reticulum is the formation of intramolecular disulfide bonds during the maturation of many secreted proteins and membrane proteins

For type 2 diabetes, denials are often fixable

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The study provides a detailed mechanistic insight into the interplay between metabolic reprogramming, protein stability, and drug response in the context of obesity and cancer

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