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The two coronavirus sites with exact P4-P1 matches to GCLC are those at either end of nsp5, i.e., M pro itself, which have the highest catalytic efficiency for cleavage of any of the viral M pro targets (100 and 41%)

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What Are the Benefits of the Myers Cocktail

In rabies virus G protein, two modalities of neutralization were described: (1) targeting an epitope on a single domain that is fully accessible only in prefusion is enough to lock the protein in prefusion conformation, hence inhibiting the fusion process 44 and (2) recognition of an epitope that spans more than three domains, including one on an adjacent protomer, prevents the conformational changes required for fusion 45

But timing still matters