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High-density miniaturized thermal shift assays as a general strategy for drug discovery

Emerging Role of GLP-1 Agonists in Obesity: A Comprehensive Review of Randomised Controlled Trials

Neuroscientist 14 , 182194 (2008)

The compound suppresses lipogenesis in a concentration-dependent manner, with doses of 30-60 M reducing lipid accumulation by 50-70% in cultured adipocytes

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The STEP clinical trials, particularly at 2.4 mg a week, revealed significant weight loss in both diabetic and non-diabetic populations, with body weight reductions ranging from 10% to 15% over extended periods (6)(23)(39)