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Oxidative stress occurs when free radical formation exceeds the ability of protection against them

Fatty acid/lipid metabolism in IR The specific insulin actions in adipose tissue include activation of glucose uptake and triglyceride synthesis, suppression of triglyceride hydrolysis and free fatty acids (FFA) and glycerol release into the blood circulation

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In ALDH2-deficient mice, exposure to exogenous formaldehyde triggered exaggerated macrophage glycolysis and proinflammatory responses, suggesting that impaired FA clearance can further amplify inflammation and metabolic dysfunction [93]

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