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Briefly, cells were treated with 100 M BSO (dissolved in culture medium) for 18 h and washed with fresh serum free DMEM followed by aspirin treatment as above

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These results support a model in which EBNA2 and MYC coordinate a redox defense program, increasing one-carbon metabolism to support glutathione biosynthesis needed to suppress ferroptosis, while also providing carbon units for de novo purine synthesis (12) (Fig

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Jayasena CN, Franks S

The less frequent dosing schedule works well for those who can't commit to multiple daily injections