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[12] [13] Patients experiencing severe gastrointestinal side effects from tirzepatide may become dehydrated, which can concentrate urine and potentially affect renal function

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The kidney conversion of Ang I toward the deleterious ACE/Ang II/angiotensin II type 1 receptor (AT 1 R) arm or the protective ACE2/angiotensin (1-7)/Mas arm depends on the activity of ACE or ACE2, respectively

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