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Notably, even when endosomal entry is blocked by bafilomycin, elastase treatment can rescue infection of SARS-CoV particles bound at the cell surface, indicating that elastase-mediated cleavage can enable membrane fusion and viral entry independently of the endosomal (cathepsin-dependent) pathway 13,14
2026 Mar 11;148(9):10225-10240
WashU Medicine has a community of faculty, staff and trainees that brings together a very special blend of intelligence, drive, warmth and humility, Perlmutter said
To analyze modification with K29-linked chains in cells, we used GST-fused TRABIDNZF1 as a K29 binder