NNMT is an enzyme involved in nicotinamide metabolism and methylation processes that influence numerous physiological pathways throughout the body
The glutathione cycle: Glutathione metabolism beyond the -glutamyl cycle [PMID: 29667297] Laboratory literature summary: The glutathione cycle: Glutathione metabolism beyond the -glutamyl cycle
Diabetic patients on insulin or sulfonylureas should monitor blood glucose closely when combining MIC injections with calorie restriction, as the combined effect can increase hypoglycemia risk during the first 23 weeks of treatment
This is probably explained by the fact that S-adenosylmethionine (SAM), which is important for many epigenetic processes, is regenerated by methylcobalamin, whereas cyanocobalamin reduces it (as we explored above)
The results aren't dramatic week to week
Evidence in humans is early, so peptide therapy should complement, not replace, established rheumatology care