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Abbreviations CALCOCO2: Calcium binding and coiled-coil domain-containing protein 2 DPP: Diabetes Prevention Program ECM: Extracellular matrix ER: Endoplasmic reticulum GLP-1: Glucagon-like peptide-1 GWAS: Genome-wide association studies HNF1A: Hepatocyte nuclear factor 1- IGT: Impaired glucose tolerance ITFG3: Integrin FG-GAP repeat containing 3 PE: Pancreatic elastase SIDD: Severe insulin-deficient diabetes TMAO: Trimethylamine N -oxide UPR: Unfolded protein response References Esser N, Utzschneider KM, Kahn SE (2020) Early beta cell dysfunction vs insulin hypersecretion as the primary event in the pathogenesis of dysglycaemia

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10.1038/s41419-020-2298-2 Cell Death Dis

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