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After an oral glucose load or a meal, this DPP-4 inhibition resulted in a 2- to 3-fold increase in circulating levels of active GLP-1 and GIP, decreased glucagon concentrations, and increased responsiveness of insulin release to glucose, resulting in higher C-peptide and insulin concentrations
Patients taking oral contraceptives should use backup contraception for 4 weeks after tirzepatide initiation and after each dose increase, as delayed gastric emptying may reduce contraceptive absorption and effectiveness
For tirzepatide, 2.5mg weekly is the standard starting dose
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Leptin resistance can lead to feelings of excessive hunger and sluggish use of stored energy (i.e., fat)
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