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We believe these data underscore the potential of CagriSema to address unmet medical needs in obesity and support long-term disease management." The NDA is based on results from REDEFINE 1, a 68-week, phase 3, randomized, double-blind, placebo-and active-controlled trial that evaluated the efficacy and safety of once-weekly CagriSema compared to semaglutide 2.4 mg alone, cagrilintide 2.4 mg alone, or placebo, all as an adjunct to lifestyle intervention in 3,417 adults with obesity (BMI 30 kg/m 2 ) or overweight (BMI 27 kg/m 2 ) with one or more obesity-related complications and without diabetes, and REDEFINE 2, a double-blind, randomized, placebo-controlled, 68-week, phase 3 trial that evaluated the efficacy and safety of once-weekly CagriSema versus placebo, as an adjunct to lifestyle intervention in 1,206 adults with type 2 diabetes and either obesity (BMI 30 kg/m 2 ) or overweight (BMI 27 kg/m 2 )

The latter, a peptide secreted by the L-cells of the digestive track, has shown greater potency regarding weight loss, fatty acid oxidation, liver steatosis and anti-hyperglycemic activity compared to equal GLP1R agonism in obese mice

Detoxifies the Body As a functional medicine nutrient, Glutathione supports the liver detox pathway, helping the body eliminate toxins and heavy metals that can dull the skin or trigger breakouts

Understanding these primary effects provides important context when considering whether Saxenda might influence other aspects of health, including sexual function

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& Draghia-Akli, R