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Beyond its cytoskeletal effects, TB-500 forms functional complexes with PINCH (particularly interesting new cysteine-histidine-rich protein) and integrin-linked kinase (ILK), activating the survival kinase Akt while inhibiting TNF--induced NF-B activation through blocking of RelA/p65 translocation
Engel JM, Muhling J, Kwapisz M, Heidt M
Poppelreuther, M
The combination of redox buffering and inflammatory damping is a recurring theme across the compound's reported applications
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