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The major actions in phase I, carried out primarily by cytochrome P450 enzymes Include: Oxidation Hydration Reduction Hydrolysis1 The Next Step: Phase II Conjugation Phase II completes the process of taking fat-soluble toxins, estrogens, and other materials and turning them into inactive, water-soluble wastes for elimination

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Brain and wakefulness Histamine is also a neurotransmitter involved in arousal, sleep-wake regulation, attention, appetite, memory and modulation of other neurotransmitter systems

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