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Because of the considerable variations in dosage, duration, administration methods, and outcome measures found in nutraceutical trials, it is challenging to perform meta-analyses and reach generalizable findings

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The GLP-1 elevations observed with allulose consumption are generally small and transient compared to those achieved with pharmaceutical GLP-1 receptor agonists such as semaglutide or liraglutide, which produce sustained and pharmacologically significant increases in GLP-1 activity

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Soluble fiber, in particular, is fermented by gut bacteria into short-chain fatty acids, like butyrate, and may promote secretion of GLP-1

Chlorophyllin was shown to be a specific inhibitor of GSTP1