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Cross talk between brain innate immunity and serotonin signaling underlies depressive-like behavior induced by Alzheimers amyloid-beta oligomers in mice
What are the Results
These two substitutions , the Nle4 and D-Phe7 modifications and were introduced through the systematic structure-activity relationship programme in Victor Hrubys laboratory at the University of Arizona that established the pharmacophore requirements for melanocortin receptor agonism and produced MT-1 as a more potent, metabolically stable, and pharmacologically tractable research tool than native -MSH
Reconstitution: 3.0 mL per 50 mg vial (16.67 mg/mL) provides practical unit measurements
Funding: SG is supported by a Crohns and Colitis Foundation Career Development Award
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