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Multiple well-designed clinical trials have demonstrated SFNs biological activity and therapeutic potential, while also revealing important considerations for its clinical implementation ( Figure 3 )

Kannan M, Sil S, Oladapo A, Thangaraj A, Periyasamy P, Buch S

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Other typical agents with reported inhibitory activities on TYR include kojic acid (111,112), methyl gentisate (113,114), ganodermanondiol (71,115), 10-hydroxy-2-decenoic acid (116), Stichopus japonicus extracts (69) and bis (4-hydroxybenzyl)sulphide (117)

The copper component is essential for many enzymatic processes in your body