Moreover, the activation of Sirtuin-1 can promote Parkin to translocate from cytosol into OMM, while inhibition of Sirtuin-1 reverses these effects ( 3.3.1.1 Polydatin Polydatin, a resveratrol glycoside isolated from traditional Chinese herb, Polygonum cuspidatum ( via the activation of Sirtuin-1
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Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin