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These include TNF-alpha, IL-1 beta, and IL-6, all of which drive joint destruction in inflammatory arthritis

Interestingly, the treatment demonstrated dose-dependent therapeutic effects, with moderate dosages proving more effective than high doses (1,000 mg/kg), possibly due to pharmacodynamic principles, where excessive concentrations saturate biological pathways and diminish therapeutic outcomes (Tyagi et al., 2025

In severe cases, skin and underlying tissue can suffer necrosis (tissue death), requiring antibiotics or surgery to treat

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Topical GHK-CU Found in serums, creams, and anti aging formulations, often combined with hyaluronic acid, antioxidants, and hydrating compounds

Its particularly effective in environments with reduced sunlight exposure