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TongJPrigeonRLDavisHWBidlingmaierMKahnSECummingsDEet al
Autophagy, a lysosome-dependent catabolic process, maintains cellular homeostasis by removing damaged organelles and misfolded proteins under physiological conditions [38]
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According to some publications, the extent and the intensity of physiological oral mucosal melanin hyperpigmentation increase with age probably owing to the cumulative effects of endogenous and extrinsic melanogenic stimuli, such as inflammatory processes, drugs, tobacco smoke, and recurrent minor functional injuries [4, 6, 11, 13]
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While these mechanisms contribute to its efficacy, they can also lead to gastrointestinal side effects, including nausea, bloating, and burping
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