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Thus, MET signaling is implicated not only in neuronal growth and maturation but also in the timing regulation of synaptic plasticity during forebrain glutamatergic circuit development ( Mechanistically, HGF-induced synapse formation is mediated by PI-3K and not MAPK activation, as inhibition of the PI-3K/AKT pathway affects synaptogenesis, while blocking MAPK/ERK does not decrease synapse density and only affects dendritic growth ( Implications of HGF-MET Gene Mutations in NDDs MET has an important role in neuron architecture construction and synapse maturation, as described in previous sections
What the Evidence Actually Supports The 2025 AAOS systematic review (Vasireddi et al.) identified 35 preclinical and only 1 human study meeting inclusion criteria
Continued research and clinical trials are essential to fully understand and utilize BPC 157s therapeutic potential in this area
Most dosage decisions are based on product format, skin sensitivity, health goals, and tolerance rather than gender alone