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Abstract Background Central sensitization is considered a critical pathogenic mechanism of chronic migraine (CM)

This leads to an increase in intracellular cAMP concentrations and activates protein kinase A (PKA), ultimately suppressing platelet activation

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Ezzedine K, Lim HW, Suzuki T, Katayama I, Hamzavi I, Lan CC, Goh BK, Anbar T, Silva de Castro C, Lee AY, Parsad D

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