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The timing hypothesis now established in the literature suggests that initiating HRT before age 60 or within 10 years of menopause is associated with a substantially more favorable risk profile and, in some analyses, active cardiovascular benefit
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The antinociceptive effect of ALC has been confirmed in several experimental models of neuropathic pain, including streptozotocin- and chemotherapy-induced neuropathy, and the sciatic nerve chronic constriction injury model
Insomnia is a sleep disorder that affects millions of people worldwide
MECC also suppressed AChE activity and reduced pro-inflammatory cytokines (TNF-, IL-1, IL-6) in the frontal cortex and hippocampus, indicating its therapeutic efficacy (Ravi et al., 2018)
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