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Nitric oxide promotes smooth muscle relaxation, and imbalanced NO signaling contributes to sphincter dysfunction

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3210-A EUTHYROID SICK SYNDROME INDICATES INCREASED RISK FOR ACUTE-ON-CHRONIC LIVER FAILURE AND MORTALITY IN PATIENTS WITH CIRRHOSIS Lukas Hartl 1,2 , Benedikt Simbrunner 3,4,5 , Mathias Jachs 2,6 , Peter Wolf 7 , David Josef Maria Bauer 1,2 , Bernhard Scheiner 1,2 , Lorenz Balcar 2,8 , Georg Semmler 1,2 , Michael Schwarz 2,6 , Rodrig Marculescu 9 , Michael Trauner 1 , Mattias Mandorfer 1,5 and Thomas Reiberger 2,3,6 , (1)Medical University of Vienna, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Vienna, Austria, (2)Medical University of Vienna, Vienna Hepatic Hemodynamic Lab, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Vienna, Austria, (3)Christian Doppler Laboratory for Portal Hypertension and Liver Fibrosis, Medical University of Vienna, (4)Cemm Research Center for Molecular Medicine of the Austrian Academy of Sciences, (5)Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, (6)Medical University of Vienna, (7)Medical University of Vienna, Division of Endocrinology, Department of Internal Medicine III, Vienna, Austria, (8)Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria, (9)Medical University of Vienna, Department of Laboratory Medicine, Vienna, Austria Background: Euthyroid sick syndrome as evident by low free triiodothyronine (fT3) levels has been described in patients with cirrhosis

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