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Blood 2011;118, 16631674, doi: Riessland, M
This can lead to the accumulation of toxins, which may contribute to fatigue, brain fog, and more serious conditions like liver dysfunction
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Chemotherapy with drugs like 5-fluorouracil has also been associated with acute thiamine deficiency by disrupting thiamine activation, so oncology patients receiving such therapy might receive parenteral thiamine supplementation as part of this B-Complex if needed