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Some may mirror or negotiate new rates, but timelines vary by payer

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Part of the discrepancy may reflect prescribing outside the NHS

A trial published in The New England Journal of Medicine (2023) demonstrated mean weight reductions of up to approximately 24% of body weight over 48 weeks in adults with obesity a potentially significant finding if confirmed in Phase 3 trials

According to a US national survey, NHANES 2015-2018, mean dietary intakes of choline were 284 mg/day for women and 390 mg/day for men

They're FDA-approved for type 2 diabetes and chronic weight management