1 z Death from CV causes, as confirmed by the event adjudication committee, includes both death from cardiovascular cause and from undetermined causes adjudicated by that committee
Therefore, this binary outcome, although recommended by guidelines and regulatory bodies [17,18,19], should be interpreted cautiously and considered alongside our primary renal outcomes of continuous eGFR and UACR changes, which better capture subtle shifts in renal risk over the examined follow-up period
Lyophilized compounds are packaged for stability
As retatrutide remains investigational, its full long-term safety profile has not been established
dose adjustment of concomitant glucose-lowering medications may be necessary [5] [6] Fatigue and dizziness : Reported in some patients, possibly related to reduced caloric intake or changes in blood glucose levels Gallbladder disorders : Including cholelithiasis (gallstones) and cholecystitis, associated with rapid weight loss Rare but serious adverse effects include acute pancreatitis (tirzepatide should be discontinued immediately if pancreatitis is suspected), severe allergic reactions (anaphylaxis), and diabetic retinopathy complications (particularly with rapid improvement in glucose control)

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