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Although most patients experience grade 1-2 pneumonitis, it can rapidly escalate to a grade 3-4 irAE with a high mortality rate (50%-60%)
2011 Apr 1;589(Pt 7):1509-10
A: Weight loss rates vary depending on individual factors, but many patients begin noticing changes within the first few weeks
Similar findings were reported in a 2025 real-world analysis of over ten thousand patients: tirzepatide lowered HbA1c by 1.3% and body weight by 10.2 kg, compared with 0.9% and 6.1 kg with semaglutide after 12 months [7]
They might benefit more from supplementation
2-Aminoadipic acid (2-AAA) (ratio: 0.7), a degradation product of lysine that has not been fully characterized, is a potential modulator of glucose homeostasis in humans
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