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Adding macrolides or low-dose theophylline to restore HDAC2 activity is a more rational approach within current treatment options

However, the specific interactions and combined effects of these peptides with other medications need careful consideration

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One phase two trial (mean age 58, with no upper age limit) demonstrated mean reduction in body weight of 15.6% in participants taking CagriSema, compared to 5.1% and 8.1% with semaglutide and cagrilintide in monotherapy, respectively, over 32 weeks