A C20 fatty diacid chain connects to lysine at position 20 through hydrophilic linkers, giving tirzepatide a strong affinity for albumin in the blood
GLP-1 medications are injectable drugs that slow digestion, reduce appetite, and improve blood sugar control, thereby reducing calorie intake and promoting weight loss
Synoviolin, an ER-resident E3 ubiquitin ligase involved in the ERAD pathway, is highly expressed in the synovium of RA patients and plays a key role in disease progression
EClinicalMedicine 55:101760 Pan HC, Chen JY, Chen HY (2024) Sodium-glucose cotransport protein 2 inhibitors in patients with type 2 diabetes and acute kidney disease
Inhibition of the cAMP-degrading enzyme phosphodiesterase 4 (PDE4) enhances and sustains these cAMP responses, and disruption of G s or cAMP signalling in AP Glp1r neurons abolishes semaglutide-induced weight loss and downstream brain-wide activation
I'm new to peptides, can you help