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By antagonizing the mu-opioid receptor, naltrexone prevents beta-endorphins from inhibiting POMC neurons, thus promoting the release of -MSH and enhancing the anorexigenic pathway

A statistically significant increase in thyroid C-cell adenomas was observed in males and females at all dose levels, and a statistically significant increase in thyroid C-cell carcinomas was observed in males at 0.01 mg/kg/day, at clinically relevant exposures

But if you struggle with bloating, gas, abdominal discomfort or irregular bowel habits, avoid the temptation to immediately add large amounts of fiber

And the injection volumes stay small enough to be comfortable at every dose level through 10mg

Resources We Trust Mayo Clinic: Fibromyalgia Cleveland Clinic: Fibromyalgia National Institute of Arthritis and Musculoskeletal and Skin Diseases: Fibromyalgia: Diagnosis, Treatment, and Steps to Take American College of Rheumatology: Fibromyalgia Arthritis Foundation: Fibromyalgia Bhargava J et al

MACE = major adverse cardiovascular events