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3.2.4 Ferroptosis and amyotrophic lateral sclerosis ALS is a lethal NDD characterized by progressive degeneration of upper and lower motor neurons in the cerebral cortex, brainstem, and spinal cord, leading to skeletal muscle atrophy, weakness, weight loss, dysarthria, dysphagia, paralysis, and ultimately death from respiratory failure (Urano et al., 2025)

doi: 10.3389/fphys.2022.843784 Received 26 December 2021 Accepted 08 February 2022 Published 10 March 2022 Volume 13 - 2022 Edited by Ana Cludia Garcia De Oliveira Duarte, Federal University of So Carlos, Brazil Reviewed by Anand Thirupathi, Ningbo University, China

Copper Metabolism Disorders: This is, without a doubt, the most critical of all GHK-Cu contraindications

No, this is not recommended

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However, by focusing only on COVID-19 patients without previous liver disease, Ponziani et al