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Meanwhile, hypoxia and cell death caused by the expansion due to adipose tissue accumulation further recruit macrophages and promote the release of tumor necrosis factor-, interleukin-6, and interleukin-1, which induce inflammatory gene transcript in endothelial cells and suppresses endothelial NOS expression [156]

The small tetrapeptide size (~390 Da) makes Epithalon subject to rapid enzymatic cleavage and renal clearance

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