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Its activity intersects two major metabolic pathways simultaneously: the NAD+ biosynthesis pathway (by consuming nicotinamide, an NAD+ precursor, NNMT competes with the NAD+ salvage pathway) and the methyl-donor pathway (by consuming SAM, NNMT reduces the availability of methyl groups for epigenetic and metabolic methylation reactions)
Presented for research literature review only Dancy BM et al
Acta Bioch Bioph Sin
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Seo, E., Kang, H., Choi, H., Choi, W
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