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Accordingly, irAEs are expected to appear in patients treated with anti-CTLA-4 (6085%), anti-PD-1 (1637%), and anti-PD-L1 (1224%)

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Specifically, recent research has suggested a bidirectional communication between metabolic dysfunction (loss of metabolic homeostasis) and cellular senescence (67, 68)

The findings on how much patients are willing to spend underscore concerns about equity in access to the breakthrough drugs while insurance coverage is sparse

doi: 10.1073/pnas.1201191109 187 SongC.WangH

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