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: Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review Xin Zhou et al
Metformin is thought to have an anorexic effect partly by promoting the secretion of GLP-1 and activating afferent inputs from the intestinal tract to the NTS [24], but there is currently no evidence that the degree of weight loss exceeds 5%, which is the standard for use as an anti-obesity drug
Patients are encouraged to report any suspected side effects via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk or Yellow Card app)
The MHRA advises patients on all GLP-1s to use contraception while taking GLP-1 medicines (including an additional barrier method for patients starting or increasing tirzepatide who are using oral contraception), as well as for a defined wash-out period afterwards before trying to get pregnant (see Figure 3)
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