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Hepatocytes take up medications, environmental chemicals, steroid hormones, bilirubin and metabolic products from the blood
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The result is a larger, sustained, dual-pathway GH pulse versus a brief single-pathway pulse
The distinct mode of CTR and AMYR engagement by Cagri revealed in the current study, together with the correlated distinctions in functional responses at individual receptors, is likely to be important in the differentiated, high efficacy, of Cagri as a first-in-class obesity drug in both preclinical animal models and in treatment of obese patients in clinical trials 2,3,4
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