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Nature 341(6238):149152 Lu B (2003) BDNF and activity-dependent synaptic modulation

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DSIP also modulates the hypothalamicpituitaryadrenal (HPA) axis, lowering nighttime cortisol spikes and reducing stressrelated arousal, which contributes to more stable circadian rhythms Peptide therapy for sleep has an excellent safety profile when administered under qualified medical supervision, with minimal side effects and no dependency risk

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