Its sole purpose is acclimation
We use a "titration" schedule, which means we gradually increase your dose every four weeks
However, specific amino acid substitutions and the N-terminal lipidation in cagrilintide induce distinct conformational dynamics in the receptor complexes compared to native amylin or other analogues
After the first month, increase the dose until you reach the max level The recommended maintenance level is: 2.4 mg/week Caution: Dosing should be determined by a licensed provider

Do Not Use Zepbound If You Have a personal or family history of medullary thyroid carcinoma Have Multiple Endocrine Neoplasia syndrome type 2 Have had a serious allergic reaction to tirzepatide or any of the ingredients in Zepbound Warnings and Precautions Severe gastrointestinal disease not recommended for patients with severe gastroparesis Acute pancreatitis Acute gallbladder disease Hypoglycemia with concomitant insulin or insulin secretagogue use Hypersensitivity reactions including anaphylaxis and angioedema Acute kidney injury Diabetic retinopathy complications in patients with a history of diabetic retinopathy Suicidal behavior and ideation monitor for new or worsening depression or unusual mood changes Pulmonary aspiration during general anesthesia or deep sedation delayed gastric emptying may increase aspiration risk Most Common Adverse Reactions Nausea, diarrhea, vomiting, constipation Abdominal pain and dyspepsia Injection site reactions Fatigue Hypersensitivity reactions Eructation, hair loss, gastroesophageal reflux disease Hormonal Contraception Interaction Zepbound may reduce the effectiveness of oral hormonal contraceptives

If you have a history of malabsorption or take many medications, discuss specific timing with your healthcare provider