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The medication comes with a boxed warning for thyroid C-cell tumors, including medullary thyroid carcinoma (MTC)
The mechanism is a hypothesis
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Some suggest splitting doses, others insist on single morning administration
Finally, one very recent study in the USA has demonstrated that in some individuals with neurological symptoms, the presence in the blood of antibodies against this receptor may interfere with the proper uptake of B12 into the brain
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