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Description

Eli Lillys investigational triple-agonist remains in Phase 3 clinical trials (the TRIUMPH program), with the earliest plausible New Drug Application filing in Q4 2026 and a potential FDA decision in 2027 or 2028

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It is widely known that mitochondrial dysfunction (high ROS production, apoptotic cells, decreased m, and low cellular ATP levels) boosts the pathogenesis of KOA because it involves lipid homeostasis and cytokine release and promotes cell apoptosis [14, 15]

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