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Because brand-name pens are manufactured only in standard doses, microdosing previously relied on compounded formulations: custom preparations made by specialty pharmacies, a practice that became common during shortages of GLP-1s declared by the Food and Drug Administration (FDA) in 2025

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This review summarizes the current research findings by which GLP-1RAs treatment of diabetic osteoporosis, postmenopausal osteoporosis and glucocorticoid-induced osteoporosis and describes possible mechanisms, such as GLP-1R/MAPK signaling pathway, GLP-1R/PI3K/AKT signaling pathway and Wnt/-catenin pathway, that are associated with GLP-1RAs and osteoporosis

These foundational theories provide a robust theoretical underpinning for constructing scientifically sound and rational AMS prediction models