Pros: Naturally occurring in the body, giving it a favorable long-term safety profile compared to many synthetic peptides Backed by decades of published research on collagen synthesis, wound healing, and antioxidant activity Available in both topical (cosmetic-legal) and injectable forms depending on desired intensity Cons: Injectable/research-grade product is not standardized or quality-controlled the way pharmaceuticals are, so purity varies significantly by vendor High topical concentrations can cause skin irritation, and there is limited long-term human trial data for injectable use Side Effects: Topical use is generally well tolerated, with occasional mild redness, tingling, or dryness at the application site
You will start at a low dose for the first month, and we will increase the dosage as your body tolerates it
Kim GN, Shin MR, Shin SH, Lee AR, Lee JY, Seo BI, et al
Your appeal should include: A letter of medical necessity from your prescriber citing your BMI, comorbidities, and prior weight-loss attempts Relevant lab work (fasting glucose, HbA1c, lipid panel) that documents obesity-related metabolic dysfunction Reference to the SELECT trial or the STEP program data showing the clinical benefit of semaglutide 2.4 mg
You deserve care that sees the full picture, not just your weight
As with any strong active, it is recommended to start with a lower level and build up your skins tolerance for the ingredient