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During the past 30 years, artemisinin derivatives, such as artesunate (AS), have been shown to have antischistosomal activity both in vitro and in animal models

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To interrogate the potential effect of the lipidation on the Cagri-bound structures, we also determined structures of the CTR and AMY 1 R bound to a Cagri analogue lacking the N-terminal lipidation (CagriBB)

Even recent anti-amyloid immunotherapies, while targeting one of the core pathologies of AD, have shown limited clinical benefit and raised concerns regarding safety, efficacy, and applicability across the disease spectrum