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1 The diagnosis and treatment of attention deficit/hyperactivity disorder (ADHD), especially among children, continues to remain a hotly debated topic today as many aspects of the condition are subjective and different systems to classify the disorder are often used by physicians from different countries
however, dysfunction can lead to a multifactorial phenotype involving mtDNA release, dysregulated bioenergetics, and altered neurogenesis as the mitochondria fail to meet the cells energy demands [11, 12]
It is one of the first inflammatory signals released when the immune system perceives a threat, and in psoriasis, it acts as a master switch that amplifies virtually every other inflammatory pathway involved
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The collapse of both astrocyte and microglia into pro-inflammatory states due to depletion of GSH, leading to sustained neuroinflammation and oxidative stress, is observed in many neurodegenerative diseases (Ferreira et al., 2013
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