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Bulk-forming laxatives such as psyllium (Metamucil) or methylcellulose (Citrucel) increase stool mass and water content, promoting natural peristalsis
Common side effects of metformin include nausea, vomiting, diarrhea, gas, indigestion, and stomach discomfort
Continued coverage (non-weight-loss indications): GLP-1s remain coverable for type 2 diabetes, ASCVD, and CKD with proper ICD-10 coding and PA
Favourable side effects Improvements in lipid and blood sugar levels The trials have demonstrated that treatment with retatrutide was associated with significant improvements in measures such as glycated hemoglobin (HbA1c), fasting glucose, insulin levels, and cholesterol levels
GLP-1 medications can be highly effective for weight loss and blood sugar management, but the digestive side effects can make treatment difficult
The most significant published evidence to date comes from a phase 2 randomised controlled trial (Jastreboff et al., New England Journal of Medicine , 2023), which demonstrated substantial dose-dependent weight loss in adults with obesity over 24 weeks, with continued weight reduction observed at 48 weeks
